ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CYP2J2

Full Name:

cytochrome P450, family 2, subfamily J, polypeptide 2

Alias:

CPJ2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p31.3-p31.2

Physical Location:

60131567-60165010 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 13110 Worm: 187705 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U37143
Fold Change:		3.64

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

CYP2J2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000775.2	NP_000766.2	NC_000001.9 range: 60131567..60165010, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005792	microsome	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0008392	arachidonic acid epoxygenase activity	Molecular Function	TAS (8631948)
GO:0050381	unspecific monooxygenase activity	Molecular Function	IEA
GO:0008016	regulation of heart contraction	Biological Process	TAS (8631948)
GO:0006690	icosanoid metabolic process	Biological Process	TAS (8631948)