ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC1A1

Full Name:

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Alias:

EAAC1|EAAT3

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9p24

Physical Location:

4480443-4577468 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 25550 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI928365
Fold Change:		-2.06

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004170.4	NP_004161.4	NC_000009.10 range: 4480443..4577468

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	TAS (7521911)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (7521911)
GO:0016020	membrane	Cellular Component	IEA
GO:0005313	L-glutamate transmembrane transporter activity	Molecular Function	TAS (7521911)
GO:0015293	symporter activity	Molecular Function	IEA
GO:0017153	sodium:dicarboxylate symporter activity	Molecular Function	IEA
GO:0006835	dicarboxylic acid transport	Biological Process	IEA
GO:0015813	L-glutamate transport	Biological Process	TAS (7521911)
GO:0006810	transport	Biological Process	IEA
GO:0007268	synaptic transmission	Biological Process	TAS (7521911)