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Gene Information
Gene ID:25550
Full Name:solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Organism:Rattus norvegicus (Rat)
Genetic Location:1q52
Physical Location:232469714-232551480 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 6505    Symbol (Name): SLC1A1 (solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1)
Ortholog Status:The human GeneID 6505 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:25550
Fold Change:1.592
P Value:<0.001
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013032.3NP_037164.3NC_005100.2 range: 232469714..232551480
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005313L-glutamate transmembrane transporter activityMolecular FunctionIDA (16128593)
GO:0017153sodium:dicarboxylate symporter activityMolecular FunctionIEA
GO:0016595glutamate bindingMolecular FunctionIDA (16128593)
GO:0015501glutamate:sodium symporter activityMolecular FunctionISS
GO:0015501glutamate:sodium symporter activityMolecular FunctionIEA
GO:0015501glutamate:sodium symporter activityMolecular FunctionIDA (16128593)
GO:0015293symporter activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (16045453)
GO:0015813L-glutamate transportBiological ProcessIDA (16128593)
GO:0006835dicarboxylic acid transportBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
GO:0051260protein homooligomerizationBiological ProcessIDA (16128593)
Other Database Cross Links
NCBI Entrez Gene:25550