ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc1a1

Full Name:

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Alias:

Eaac1|Eaat3|REAAC1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q52

Physical Location:

232469714-232551480 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6505 Symbol (Name): SLC1A1 (solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1)

Ortholog Status:

The human GeneID 6505 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		25550
Fold Change:		1.592
P Value:		<0.001
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013032.3	NP_037164.3	NC_005100.2 range: 232469714..232551480

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005313	L-glutamate transmembrane transporter activity	Molecular Function	IDA (16128593)
GO:0017153	sodium:dicarboxylate symporter activity	Molecular Function	IEA
GO:0016595	glutamate binding	Molecular Function	IDA (16128593)
GO:0015501	glutamate:sodium symporter activity	Molecular Function	ISS
GO:0015501	glutamate:sodium symporter activity	Molecular Function	IEA
GO:0015501	glutamate:sodium symporter activity	Molecular Function	IDA (16128593)
GO:0015293	symporter activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16045453)
GO:0015813	L-glutamate transport	Biological Process	IDA (16128593)
GO:0006835	dicarboxylic acid transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0051260	protein homooligomerization	Biological Process	IDA (16128593)