ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GNB5

Full Name:

guanine nucleotide binding protein (G protein), beta 5

Alias:

FLJ37457|FLJ43714|GB5

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

15q21.2

Physical Location:

50200414-50270856 on NC_000015.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14697 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF017656
Fold Change:		-2

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IDA (11256614)
GO:0005834	heterotrimeric G-protein complex	Cellular Component	NAS
GO:0003924	GTPase activity	Molecular Function	NAS (9606987)
GO:0004871	signal transducer activity	Molecular Function	NAS (9606987)
GO:0007165	signal transduction	Biological Process	NAS (9606987)