ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gnb5

Full Name:

guanine nucleotide binding protein (G protein), beta 5

Alias:

GBS|Gbeta5|flr

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 D|9 41.0 cM

Physical Location:

75159201-75193477 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10681 Symbol (Name): GNB5 (guanine nucleotide binding protein (G protein), beta 5)

Ortholog Status:

The human GeneID 10681 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gnb5
Original ID2:		L34290

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (15897264)
GO:0005834	heterotrimeric G-protein complex	Cellular Component	RCA (12466851)
GO:0005886	plasma membrane	Cellular Component	IDA (15897264)
GO:0003924	GTPase activity	Molecular Function	RCA (12466851)
GO:0004871	signal transducer activity	Molecular Function	RCA (12466851)
GO:0005515	protein binding	Molecular Function	IPI (15897264)
GO:0007165	signal transduction	Biological Process	RCA (12466851)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IDA (15897264)