ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MAL

Full Name:

mal, T-cell differentiation protein

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2cen-q13

Physical Location:

95055205-95083461 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 17153 Rat: 25263 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X76220
Fold Change:		2.77

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

MAL

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005768	endosome	Cellular Component	TAS (9003426)
GO:0005783	endoplasmic reticulum	Cellular Component	IDA (8132541)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9003426)
GO:0045121	membrane raft	Cellular Component	IDA (12153479)
GO:0016324	apical plasma membrane	Cellular Component	TAS (10739088)
GO:0016505	apoptotic protease activator activity	Molecular Function	NAS (10366425)
GO:0015267	channel activity	Molecular Function	TAS (3494249)
GO:0008289	lipid binding	Molecular Function	TAS (10739088)
GO:0019911	structural constituent of myelin sheath	Molecular Function	IDA (12153479)
GO:0042552	myelination	Biological Process	NAS (12153479)
GO:0042552	myelination	Biological Process	TAS (10428054)
GO:0030154	cell differentiation	Biological Process	TAS (10739088)
GO:0001766	membrane raft polarization	Biological Process	TAS (12153479)
GO:0007417	central nervous system development	Biological Process	TAS (10739088)
GO:0006917	induction of apoptosis	Biological Process	NAS (10366425)
GO:0045176	apical protein localization	Biological Process	TAS (10739088)