ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mal

Full Name:

myelin and lymphocyte protein, T-cell differentiation protein

Alias:

MALGENE

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q36

Physical Location:

115166670-115190431 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4118 Symbol (Name): MAL (mal, T-cell differentiation protein)

Ortholog Status:

The human GeneID 4118 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mal
Fold Change:		1.12
P Value:		0.007
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012798.1	NP_036930.1	NC_005102.2 range: 115166670..115190431, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000300	peripheral to membrane of membrane fraction	Cellular Component	IDA (12153479)
GO:0045121	membrane raft	Cellular Component	IDA (9634556)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	ISS
GO:0045121	membrane raft	Cellular Component	ISS
GO:0019911	structural constituent of myelin sheath	Molecular Function	IDA (12153479)
GO:0019911	structural constituent of myelin sheath	Molecular Function	ISS
GO:0006917	induction of apoptosis	Biological Process	ISS
GO:0006886	intracellular protein transport	Biological Process	TAS (12153479)
GO:0042552	myelination	Biological Process	IDA (7643216)