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Gene Information
Gene ID:5156
Symbol:PDGFRA
Full Name:platelet-derived growth factor receptor, alpha polypeptide
Alias:CD140A|MGC74795|PDGFR2|Rhe-PDGFRA
Organism:Homo sapiens (Human)
Chromosome:4
Genetic Location:4q11-q13
Physical Location:54790203-54859168 on NC_000004.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M21574
Fold Change:2.35
Dataset Information
Name:15236863
Method:Microarray
Tissue:Prefrontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006206.4NP_006197.1NC_000004.10 range: 54790203..54859168
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentIDA (2536956)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0046982protein heterodimerization activityMolecular FunctionIDA (2542288)
GO:0042803protein homodimerization activityMolecular FunctionIDA (2542288)
GO:0016740transferase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005161platelet-derived growth factor receptor bindingMolecular FunctionIPI (2542288)
GO:0048407platelet-derived growth factor bindingMolecular FunctionIPI (2536956|10806482)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005018platelet-derived growth factor alpha-receptor activityMolecular FunctionIDA (2536956|10806482)
GO:0005021vascular endothelial growth factor receptor activityMolecular FunctionIEA
GO:0018108peptidyl-tyrosine phosphorylationBiological ProcessIDA (2536956)
GO:0030335positive regulation of cell migrationBiological ProcessIDA (17470632)
GO:0046777protein amino acid autophosphorylationBiological ProcessIDA (2536956)
GO:0001775cell activationBiological ProcessTAS (10508235)
GO:0048008platelet-derived growth factor receptor signaling pathwayBiological ProcessIDA (2536956|10806482)
GO:0048146positive regulation of fibroblast proliferationBiological ProcessIDA (10806482)
GO:0045740positive regulation of DNA replicationBiological ProcessIDA (10806482)
Other Database Cross Links
NCBI Entrez Gene:5156
HGNC:8803
Ensembl:ENSG00000134853
MIM:173490
HPRD:01429
HuGE Navigator:5156
dbSNP:PDGFRA
GeneCard:PDGFRA
AceView:PDGFRA