ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PDGFRA

Full Name:

platelet-derived growth factor receptor, alpha polypeptide

Alias:

CD140A|MGC74795|PDGFR2|Rhe-PDGFRA

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q11-q13

Physical Location:

54790203-54859168 on NC_000004.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M21574
Fold Change:		2.35

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006206.4	NP_006197.1	NC_000004.10 range: 54790203..54859168

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	IDA (2536956)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0046982	protein heterodimerization activity	Molecular Function	IDA (2542288)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (2542288)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005161	platelet-derived growth factor receptor binding	Molecular Function	IPI (2542288)
GO:0048407	platelet-derived growth factor binding	Molecular Function	IPI (2536956\|10806482)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005018	platelet-derived growth factor alpha-receptor activity	Molecular Function	IDA (2536956\|10806482)
GO:0005021	vascular endothelial growth factor receptor activity	Molecular Function	IEA
GO:0018108	peptidyl-tyrosine phosphorylation	Biological Process	IDA (2536956)
GO:0030335	positive regulation of cell migration	Biological Process	IDA (17470632)
GO:0046777	protein amino acid autophosphorylation	Biological Process	IDA (2536956)
GO:0001775	cell activation	Biological Process	TAS (10508235)
GO:0048008	platelet-derived growth factor receptor signaling pathway	Biological Process	IDA (2536956\|10806482)
GO:0048146	positive regulation of fibroblast proliferation	Biological Process	IDA (10806482)
GO:0045740	positive regulation of DNA replication	Biological Process	IDA (10806482)