ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CD74

Full Name:

CD74 molecule, major histocompatibility complex, class II invariant chain

Alias:

DHLAG|HLADG|Ia-GAMMA|protein 41

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q32

Physical Location:

149761392-149772524 on NC_000005.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M13560
Fold Change:		-2.72

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	TAS (12782713)
GO:0016021	integral to membrane	Cellular Component	TAS (6324166)
GO:0016020	membrane	Cellular Component	IEA
GO:0042289	MHC class II protein binding	Molecular Function	NAS (10981873)
GO:0042802	identical protein binding	Molecular Function	TAS (12782713)
GO:0019955	cytokine binding	Molecular Function	IPI (12782713)
GO:0042289	MHC class II protein binding	Molecular Function	IEA
GO:0001516	prostaglandin biosynthetic process	Biological Process	IDA (12782713)
GO:0043030	regulation of macrophage activation	Biological Process	NAS (12782713)
GO:0043066	negative regulation of apoptosis	Biological Process	IDA (12782713)
GO:0019883	antigen processing and presentation of endogenous antigen	Biological Process	NAS (10981873)
GO:0019882	antigen processing and presentation	Biological Process	IEA
GO:0016064	immunoglobulin mediated immune response	Biological Process	ISS
GO:0008283	cell proliferation	Biological Process	IDA (12782713)
GO:0007165	signal transduction	Biological Process	IDA (12782713)
GO:0006955	immune response	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	ISS
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0006461	protein complex assembly	Biological Process	ISS
GO:0045058	T cell selection	Biological Process	NAS (10981873)