ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MAP4K4

Full Name:

mitogen-activated protein kinase kinase kinase kinase 4

Alias:

FLH21957|FLJ10410|FLJ20373|FLJ90111|HGK|KIAA0687|NIK

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q11.2-q12

Physical Location:

101680919-101877583 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 26921 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AB014587
Fold Change:		2.89

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (9890973)
GO:0005083	small GTPase regulator activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (9890973)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (9890973)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006950	response to stress	Biological Process	IDA (9890973)
GO:0007243	protein kinase cascade	Biological Process	IDA (9890973)