ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ZEB1

Full Name:

zinc finger E-box binding homeobox 1

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10p11.2

Physical Location:

31648147-31856741 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D15050
Fold Change:		-2.04

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

ZEB1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_030751.4	NP_110378.3	NC_000010.9 range: 31648147..31856741

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0008270	zinc ion binding	Molecular Function	TAS (8138542)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0003714	transcription corepressor activity	Molecular Function	TAS (8138542)
GO:0003713	transcription coactivator activity	Molecular Function	TAS (8138542)
GO:0003700	transcription factor activity	Molecular Function	TAS (8138542)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008283	cell proliferation	Biological Process	TAS (1840704)
GO:0006955	immune response	Biological Process	TAS (1840704)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (1840704)