ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TOP3B

Full Name:

topoisomerase (DNA) III beta

Alias:

FLJ39376

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q11.22

Physical Location:

20641402-20667146 on NC_000022.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 31565 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D87012
Fold Change:		3.07

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003935.3	NP_003926.1	NC_000022.9 range: 20641402..20667146, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (9786843)
GO:0005694	chromosome	Cellular Component	IEA
GO:0003917	DNA topoisomerase type I activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15231747)
GO:0006265	DNA topological change	Biological Process	IEA
GO:0006268	DNA unwinding during replication	Biological Process	IEA
GO:0006304	DNA modification	Biological Process	IEA