ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Top3beta

Alias:

CG3458|TOP3|Topo IIIbeta|top3[beta]|topo III[beta]

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

5E5-5E5

Physical Location:

6178170-6181996 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8940 Symbol (Name): TOP3B (topoisomerase (DNA) III beta)

Ortholog Status:

The human GeneID 8940 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Top3
P Value:		3.76E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_078504.2	NP_511059.2	NC_004354.3 range: 6178170..6181996, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005694	chromosome	Cellular Component	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004812	aminoacyl-tRNA ligase activity	Molecular Function	IEA
GO:0004520	endodeoxyribonuclease activity	Molecular Function	IDA (12023976)
GO:0003917	DNA topoisomerase type I activity	Molecular Function	NAS
GO:0003917	DNA topoisomerase type I activity	Molecular Function	ISS
GO:0003916	DNA topoisomerase activity	Molecular Function	NAS
GO:0003916	DNA topoisomerase activity	Molecular Function	IDA (12023976)
GO:0006304	DNA modification	Biological Process	IEA
GO:0006268	DNA unwinding during replication	Biological Process	IEA
GO:0006265	DNA topological change	Biological Process	IEA
GO:0000737	DNA catabolic process, endonucleolytic	Biological Process	IDA (12023976)
GO:0006418	tRNA aminoacylation for protein translation	Biological Process	IEA