ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HLA-DPB1

Full Name:

major histocompatibility complex, class II, DP beta 1

Alias:

DPB1|HLA-DP1B|MHC DPB1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p21.3

Physical Location:

33151737-33162953 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M83664
Fold Change:		-2.03

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002121.4	NP_002112.3	NC_000006.10 range: 33151737..33162953

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	EXP (11048639\|11827988\|15489916\|17652306)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0042613	MHC class II protein complex	Cellular Component	IEA
GO:0032395	MHC class II receptor activity	Molecular Function	TAS (8105536)
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0009405	pathogenesis	Biological Process	TAS (8105536)