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Gene Information
Gene ID:29253
Full Name:monoamine oxidase A
Organism:Rattus norvegicus (Rat)
Physical Location:17678535-17747005 on NC_005120.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4128    Symbol (Name): MAOA (monoamine oxidase A)
Ortholog Status:The human GeneID 4128 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:D00688
Fold Change:2.5
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_343764.3XP_343765.1NC_005120.2 range: 17678535..17747005, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0005741mitochondrial outer membraneCellular ComponentIEA
GO:0005741mitochondrial outer membraneCellular ComponentIDA (11263670)
GO:0005739mitochondrionCellular ComponentISS
GO:0005739mitochondrionCellular ComponentIEA
GO:0005625soluble fractionCellular ComponentIDA (11754741)
GO:0016020membraneCellular ComponentIEA
GO:0051378serotonin bindingMolecular FunctionIDA (11263670|11754741)
GO:0050660FAD bindingMolecular FunctionIMP (11754741)
GO:0050660FAD bindingMolecular FunctionIDA (11754741)
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0008131amine oxidase activityMolecular FunctionIMP (11754741)
GO:0005515protein bindingMolecular FunctionISS
GO:0008131amine oxidase activityMolecular FunctionIDA (11263670|11754741|12388421)
GO:0051378serotonin bindingMolecular FunctionIMP (11754741)
GO:0008131amine oxidase activityMolecular FunctionIEA
GO:0042424catecholamine catabolic processBiological ProcessNAS (12388421)
GO:0042428serotonin metabolic processBiological ProcessIDA (11263670|11754741)
GO:0042420dopamine catabolic processBiological ProcessISS
GO:0042443phenylethylamine metabolic processBiological ProcessIDA (11754741)
GO:0042443phenylethylamine metabolic processBiological ProcessIMP (11754741)
GO:0042420dopamine catabolic processBiological ProcessIEA
GO:0006584catecholamine metabolic processBiological ProcessIEA
GO:0042428serotonin metabolic processBiological ProcessIMP (11754741)
Other Database Cross Links
NCBI Entrez Gene:29253