ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

29253

Symbol:

Maoa

Full Name:

monoamine oxidase A

Alias:

Mao

Organism:

Rattus norvegicus (Rat)

Chromosome:

Physical Location:

17678535-17747005 on NC_005120.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4128 Symbol (Name): MAOA (monoamine oxidase A)

Ortholog Status:

The human GeneID 4128 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D00688
Fold Change:		2.5
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_343764.3	XP_343765.1	NC_005120.2 range: 17678535..17747005, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005741	mitochondrial outer membrane	Cellular Component	IEA
GO:0005741	mitochondrial outer membrane	Cellular Component	IDA (11263670)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005625	soluble fraction	Cellular Component	IDA (11754741)
GO:0016020	membrane	Cellular Component	IEA
GO:0051378	serotonin binding	Molecular Function	IDA (11263670\|11754741)
GO:0050660	FAD binding	Molecular Function	IMP (11754741)
GO:0050660	FAD binding	Molecular Function	IDA (11754741)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0008131	amine oxidase activity	Molecular Function	IMP (11754741)
GO:0005515	protein binding	Molecular Function	ISS
GO:0008131	amine oxidase activity	Molecular Function	IDA (11263670\|11754741\|12388421)
GO:0051378	serotonin binding	Molecular Function	IMP (11754741)
GO:0008131	amine oxidase activity	Molecular Function	IEA
GO:0042424	catecholamine catabolic process	Biological Process	NAS (12388421)
GO:0042428	serotonin metabolic process	Biological Process	IDA (11263670\|11754741)
GO:0042420	dopamine catabolic process	Biological Process	ISS
GO:0042443	phenylethylamine metabolic process	Biological Process	IDA (11754741)
GO:0042443	phenylethylamine metabolic process	Biological Process	IMP (11754741)
GO:0042420	dopamine catabolic process	Biological Process	IEA
GO:0006584	catecholamine metabolic process	Biological Process	IEA
GO:0042428	serotonin metabolic process	Biological Process	IMP (11754741)