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Gene Information
Gene ID:81736
Full Name:nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
Organism:Rattus norvegicus (Rat)
Genetic Location:2q43
Physical Location:233091017-233211296 on NC_005101.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4790    Symbol (Name): NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105))
Ortholog Status:The human GeneID 4790 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L26267
Fold Change:2.7
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Information
Original ID1:81736
Fold Change:0.535
P Value:0.0135
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_342346.3XP_342347.2NC_005101.2 range: 233091017..233211296, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIDA (12193536)
GO:0005634nucleusCellular ComponentTAS (12193536)
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (16135962)
GO:0005829cytosolCellular ComponentIDA (16135962)
GO:0043234protein complexCellular ComponentIDA (16135962)
GO:0046983protein dimerization activityMolecular FunctionIDA (14576180)
GO:0016563transcription activator activityMolecular FunctionIDA (14576180)
GO:0016566specific transcriptional repressor activityMolecular FunctionISS
GO:0031072heat shock protein bindingMolecular FunctionIPI (16135962)
GO:0042803protein homodimerization activityMolecular FunctionISS
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (16135962)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionTAS (14576180)
GO:0003677DNA bindingMolecular FunctionISS
GO:0003690double-stranded DNA bindingMolecular FunctionIDA (14576180)
GO:0003700transcription factor activityMolecular FunctionTAS (12193536)
GO:0003779actin bindingMolecular FunctionIPI (15777838)
GO:0005515protein bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (11313306|15728586|16135962)
GO:0005515protein bindingMolecular FunctionISS
GO:0007165signal transductionBiological ProcessIEA
GO:0046688response to copper ionBiological ProcessIEP (17418555)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (14576180)
GO:0045892negative regulation of transcription, DNA-dependentBiological ProcessISS
GO:0045083negative regulation of interleukin-12 biosynthetic processBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006916anti-apoptosisBiological ProcessIMP (16354757)
GO:0006979response to oxidative stressBiological ProcessIDA (12193536)
GO:0006350transcriptionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:81736