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Gene Information
Gene ID:4790
Full Name:nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
Organism:Homo sapiens (Human)
Genetic Location:4q24
Physical Location:103641517-103757506 on NC_000004.10
Gene Type:protein-coding
Orthologs:This gene has Rat: 81736 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:NFKB1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
NFKB11Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Linkage Dataset
MarkerLODP valueLocation (bp)
Phenotype:ADSX (number of DSM-IV AD symptoms)
Publication:Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed
Summary:We conducted a genome scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). A 4 cM genome scan was conducted using 474 families of which most (96%) were comprised by affected sib pairs. Nonparametric and quantitative linkage analyses were conducted using DSM-IV alcohol dependence (AD) and number of DSM-IV AD symptoms (ADSX). Quantitative results indicate strong linkage for number of AD criteria to a broad region of chromosome 4, ranging from 4q22 to 4q32 (peak multipoint LOD=4.59, P=2.1 x 10(-6), at D4S1611). We got the gene list in the region between two markers D4S423 and D4S427 as markers between (included) these two markers have LOD scores >2 with P value <0.0003.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003998.2NP_003989.2NC_000004.10 range: 103641517..103757506
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (11819787)
GO:0005654nucleoplasmCellular ComponentEXP (10723127)
GO:0005737cytoplasmCellular ComponentIDA (11819787)
GO:0005829cytosolCellular ComponentEXP (10723127)
GO:0003700transcription factor activityMolecular FunctionTAS (10928981)
GO:0005515protein bindingMolecular FunctionIPI (8196632|11526476|14624448|16108830|16306601)
GO:0007165signal transductionBiological ProcessIEA
GO:0006954inflammatory responseBiological ProcessTAS (1992489)
GO:0006916anti-apoptosisBiological ProcessTAS (10811897)
GO:0006915apoptosisBiological ProcessIEA
GO:0006366transcription from RNA polymerase II promoterBiological ProcessTAS (1992489)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0045941positive regulation of transcriptionBiological ProcessNAS (8096091)
Other Database Cross Links
NCBI Entrez Gene:4790
HuGE Navigator:4790