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Gene Information
Gene ID:25592
Full Name:agrin
Organism:Rattus norvegicus (Rat)
Genetic Location:5q36
Physical Location:172999419-173020763 on NC_005104.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 375790    Symbol (Name): AGRN (agrin)
Ortholog Status:The human GeneID 375790 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M64780
Fold Change:2.8
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Information
Original ID1:Rn.2163
Original ID2:Agrn
Fold Change:1.15
P Value:0.00245
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_175754.1NP_786930.1NC_005104.2 range: 172999419..173020763, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005578proteinaceous extracellular matrixCellular ComponentTAS (15711988)
GO:0005604basement membraneCellular ComponentIDA (15711988)
GO:0005605basal laminaCellular ComponentIEA
GO:0005605basal laminaCellular ComponentISS
GO:0005615extracellular spaceCellular ComponentISS
GO:0009986cell surfaceCellular ComponentISS
GO:0030548acetylcholine receptor regulator activityMolecular FunctionISS
GO:0043236laminin bindingMolecular FunctionIEA
GO:0043113receptor clusteringBiological ProcessISS
GO:0043113receptor clusteringBiological ProcessIEA
GO:0045213neurotransmitter receptor metabolic processBiological ProcessISS
GO:0008582regulation of synaptic growth at neuromuscular junctionBiological ProcessISS
GO:0007528neuromuscular junction developmentBiological ProcessTAS (15711988)
GO:0007528neuromuscular junction developmentBiological ProcessISS
GO:0007416synaptogenesisBiological ProcessIMP (12486121)
GO:0007268synaptic transmissionBiological ProcessISS
GO:0007268synaptic transmissionBiological ProcessIMP (15883200)
GO:0007213acetylcholine receptor signaling, muscarinic pathwayBiological ProcessIEA
GO:0007009plasma membrane organization and biogenesisBiological ProcessISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25592