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Gene Information
Gene ID:25513
Full Name:phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
Organism:Rattus norvegicus (Rat)
Genetic Location:2q12
Physical Location:32602672-32675349 on NC_005101.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5295    Symbol (Name): PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha))
Ortholog Status:The human GeneID 5295 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U50412
Fold Change:6.7
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013005.1NP_037137.1NC_005101.2 range: 32602672..32675349, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentISS
GO:0016020membraneCellular ComponentISS
GO:0005942phosphoinositide 3-kinase complexCellular ComponentTAS (8621382)
GO:0005886plasma membraneCellular ComponentIDA (11826414)
GO:0005829cytosolCellular ComponentISS
GO:0019903protein phosphatase bindingMolecular FunctionISS
GO:00163031-phosphatidylinositol-3-kinase activityMolecular FunctionTAS (8621382)
GO:0019901protein kinase bindingMolecular FunctionIPI (15530849)
GO:0043560insulin receptor substrate bindingMolecular FunctionISS
GO:0043560insulin receptor substrate bindingMolecular FunctionIPI (12891559)
GO:0043559insulin bindingMolecular FunctionISS
GO:0008022protein C-terminus bindingMolecular FunctionIDA (12692262)
GO:0043125ErbB-3 class receptor bindingMolecular FunctionISS
GO:0005102receptor bindingMolecular FunctionIPI (14962484)
GO:0005158insulin receptor bindingMolecular FunctionISS
GO:0005159insulin-like growth factor receptor bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIDA (15731459)
GO:0043627response to estrogen stimulusBiological ProcessIPI (16971528)
GO:0045663positive regulation of myoblast differentiationBiological ProcessIMP (9440811)
GO:0045671negative regulation of osteoclast differentiationBiological ProcessISS
GO:0051384response to glucocorticoid stimulusBiological ProcessIDA (15187100)
GO:0045768positive regulation of anti-apoptosisBiological ProcessIMP (15089039)
GO:0045861negative regulation of proteolysisBiological ProcessIMP (15161606)
GO:0048009insulin-like growth factor receptor signaling pathwayBiological ProcessISS
GO:0048009insulin-like growth factor receptor signaling pathwayBiological ProcessIMP (9440811)
GO:0043066negative regulation of apoptosisBiological ProcessISS
GO:0006006glucose metabolic processBiological ProcessIMP (9440811)
GO:0006468protein amino acid phosphorylationBiological ProcessISS
GO:0007568agingBiological ProcessIEP
GO:0008286insulin receptor signaling pathwayBiological ProcessIMP (15161606)
GO:0008286insulin receptor signaling pathwayBiological ProcessISS
GO:0001953negative regulation of cell-matrix adhesionBiological ProcessISS
GO:0022408negative regulation of cell-cell adhesionBiological ProcessIMP (15530849)
GO:0030183B cell differentiationBiological ProcessISS
GO:0030335positive regulation of cell migrationBiological ProcessIMP (15530849)
GO:0030335positive regulation of cell migrationBiological ProcessISS
GO:0032868response to insulin stimulusBiological ProcessIDA (16150536)
GO:0051591response to cAMPBiological ProcessIDA (10875243)
Other Database Cross Links
NCBI Entrez Gene:25513