ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

25513

Symbol:

Pik3r1

Full Name:

phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)

Alias:

PI3KA

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q12

Physical Location:

32602672-32675349 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5295 Symbol (Name): PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha))

Ortholog Status:

The human GeneID 5295 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U50412
Fold Change:		6.7
Tissue:		Amygdala

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013005.1	NP_037137.1	NC_005101.2 range: 32602672..32675349, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0016020	membrane	Cellular Component	ISS
GO:0005942	phosphoinositide 3-kinase complex	Cellular Component	TAS (8621382)
GO:0005886	plasma membrane	Cellular Component	IDA (11826414)
GO:0005829	cytosol	Cellular Component	ISS
GO:0019903	protein phosphatase binding	Molecular Function	ISS
GO:0016303	1-phosphatidylinositol-3-kinase activity	Molecular Function	TAS (8621382)
GO:0019901	protein kinase binding	Molecular Function	IPI (15530849)
GO:0043560	insulin receptor substrate binding	Molecular Function	ISS
GO:0043560	insulin receptor substrate binding	Molecular Function	IPI (12891559)
GO:0043559	insulin binding	Molecular Function	ISS
GO:0008022	protein C-terminus binding	Molecular Function	IDA (12692262)
GO:0043125	ErbB-3 class receptor binding	Molecular Function	ISS
GO:0005102	receptor binding	Molecular Function	IPI (14962484)
GO:0005158	insulin receptor binding	Molecular Function	ISS
GO:0005159	insulin-like growth factor receptor binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IDA (15731459)
GO:0043627	response to estrogen stimulus	Biological Process	IPI (16971528)
GO:0045663	positive regulation of myoblast differentiation	Biological Process	IMP (9440811)
GO:0045671	negative regulation of osteoclast differentiation	Biological Process	ISS
GO:0051384	response to glucocorticoid stimulus	Biological Process	IDA (15187100)
GO:0045768	positive regulation of anti-apoptosis	Biological Process	IMP (15089039)
GO:0045861	negative regulation of proteolysis	Biological Process	IMP (15161606)
GO:0048009	insulin-like growth factor receptor signaling pathway	Biological Process	ISS
GO:0048009	insulin-like growth factor receptor signaling pathway	Biological Process	IMP (9440811)
GO:0043066	negative regulation of apoptosis	Biological Process	ISS
GO:0006006	glucose metabolic process	Biological Process	IMP (9440811)
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0007568	aging	Biological Process	IEP
GO:0008286	insulin receptor signaling pathway	Biological Process	IMP (15161606)
GO:0008286	insulin receptor signaling pathway	Biological Process	ISS
GO:0001953	negative regulation of cell-matrix adhesion	Biological Process	ISS
GO:0022408	negative regulation of cell-cell adhesion	Biological Process	IMP (15530849)
GO:0030183	B cell differentiation	Biological Process	ISS
GO:0030335	positive regulation of cell migration	Biological Process	IMP (15530849)
GO:0030335	positive regulation of cell migration	Biological Process	ISS
GO:0032868	response to insulin stimulus	Biological Process	IDA (16150536)
GO:0051591	response to cAMP	Biological Process	IDA (10875243)