| Gene Information |
| Gene ID: | | 29598 |
| Symbol: | | Atp2b1 |
| Full Name: | | ATPase, Ca++ transporting, plasma membrane 1 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 7 |
| Genetic Location: | | 7q13 |
| Physical Location: | | 36493660-36600279 on NC_005106.2 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 490 Symbol (Name): ATP2B1 (ATPase, Ca++ transporting, plasma membrane 1) |
| Ortholog Status: | | The human GeneID 490 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | J03753 | | Fold Change: | | -4.2 | | Tissue: | | Amygdala |
| | Dataset Information | | Name: | | 11772933 | | Method: | | Microarray | | Tissue: | | Frontal cortex and amygdala | | Phenotype: | | Ethanol response | | Publication: | | Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed | | Summary: | | Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats. |
| | Gene Information | | Original ID1: | | 29598 | | Fold Change: | | 1.477 | | P Value: | | 0.0265 | | Note: | | Fold change is average ratio of AA to ANA. |
| | Dataset Information | | Name: | | 15846778 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed | | Summary: | | DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats. |
| | Gene Information | | Original ID1: | | Atp2b1 | | Fold Change: | | 1.22 | | P Value: | | 0.001 | | Note: | | Differential expression between ethanol and water groups in nucleus accumbens |
| | Dataset Information | | Name: | | 18405950 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens and amygdala | | Phenotype: | | Ethanol self-administration, alcohol-preferring | | Publication: | | Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed | | Summary: | | The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005515 | protein binding | Molecular Function | ISS | |
| GO:0030165 | PDZ domain binding | Molecular Function | IPI (16554037) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 29598 |
| RGD: | | 621303 |
| Ensembl: | | ENSRNOG00000004026 |
| dbSNP: | | Atp2b1 |
