Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:64678
Full Name:transferrin receptor
Organism:Rattus norvegicus (Rat)
Genetic Location:11q22
Physical Location:69976255-69998097 on NC_005110.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7037    Symbol (Name): TFRC (transferrin receptor (p90, CD71))
Ortholog Status:The human GeneID 7037 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M58040
Fold Change:2.7
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_340999.3XP_341000.3NC_005110.2 range: 69976255..69998097, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0048471perinuclear region of cytoplasmCellular ComponentISS
GO:0016023cytoplasmic membrane-bounded vesicleCellular ComponentIEA
GO:0016023cytoplasmic membrane-bounded vesicleCellular ComponentISS
GO:0005886plasma membraneCellular ComponentISS
GO:0005886plasma membraneCellular ComponentIEA
GO:0005768endosomeCellular ComponentISS
GO:0005768endosomeCellular ComponentIEA
GO:0005576extracellular regionCellular ComponentISS
GO:0005576extracellular regionCellular ComponentIEA
GO:0042470melanosomeCellular ComponentIEA
GO:0048471perinuclear region of cytoplasmCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0004998transferrin receptor activityMolecular FunctionTAS (9380695)
GO:0004998transferrin receptor activityMolecular FunctionIDA (12707050)
GO:0006897endocytosisBiological ProcessIEA
GO:0006879cellular iron ion homeostasisBiological ProcessISS
GO:0006879cellular iron ion homeostasisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:64678