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Gene Information
Gene ID:29154
Full Name:calpain 2
Organism:Rattus norvegicus (Rat)
Genetic Location:13q26
Physical Location:98473366-98524462 on NC_005112.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 824    Symbol (Name): CAPN2 (calpain 2, (m/II) large subunit)
Ortholog Status:The human GeneID 824 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L09120
Fold Change:-2.3
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017116.2NP_058812.1NC_005112.2 range: 98473366..98524462, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005626insoluble fractionCellular ComponentIDA (17429681)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentTAS (14976200)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005622intracellularCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIDA (14976200)
GO:0004198calcium-dependent cysteine-type endopeptidase activityMolecular FunctionIPI (8218419)
GO:0004198calcium-dependent cysteine-type endopeptidase activityMolecular FunctionIEA
GO:0004198calcium-dependent cysteine-type endopeptidase activityMolecular FunctionIDA (14976200|17429681)
GO:0008092cytoskeletal protein bindingMolecular FunctionIDA (17429681)
GO:0007520myoblast fusionBiological ProcessISS
GO:0007520myoblast fusionBiological ProcessIEA
GO:0006508proteolysisBiological ProcessTAS (14976200)
GO:0006508proteolysisBiological ProcessIEA
GO:0006508proteolysisBiological ProcessIDA (17429681)
GO:0001666response to hypoxiaBiological ProcessIEP (15979593)
GO:0001824blastocyst developmentBiological ProcessISS
GO:0016540protein autoprocessingBiological ProcessIC (17429681)
Other Database Cross Links
NCBI Entrez Gene:29154