ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Capn2

Full Name:

calpain 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q26

Physical Location:

98473366-98524462 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 824 Symbol (Name): CAPN2 (calpain 2, (m/II) large subunit)

Ortholog Status:

The human GeneID 824 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017116.2	NP_058812.1	NC_005112.2 range: 98473366..98524462, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005626	insoluble fraction	Cellular Component	IDA (17429681)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	TAS (14976200)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IDA (14976200)
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Molecular Function	IPI (8218419)
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Molecular Function	IEA
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Molecular Function	IDA (14976200\|17429681)
GO:0008092	cytoskeletal protein binding	Molecular Function	IDA (17429681)
GO:0007520	myoblast fusion	Biological Process	ISS
GO:0007520	myoblast fusion	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	TAS (14976200)
GO:0006508	proteolysis	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	IDA (17429681)
GO:0001666	response to hypoxia	Biological Process	IEP (15979593)
GO:0001824	blastocyst development	Biological Process	ISS
GO:0016540	protein autoprocessing	Biological Process	IC (17429681)