ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nptxr

Full Name:

neuronal pentraxin receptor

Alias:

Npr

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q34

Physical Location:

118023924-118041728 on NC_005106.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23467 Symbol (Name): NPTXR (neuronal pentraxin receptor)

Ortholog Status:

The human GeneID 23467 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF005099
Fold Change:		2.4
Tissue:		Medial prefrontal (cingulate) cortex

Gene Information

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_030841.3	NP_110468.2	NC_005106.2 range: 118023924..118041728, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	IDA (10748068)
GO:0005886	plasma membrane	Cellular Component	IDA (10748068)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0008029	pentraxin receptor activity	Molecular Function	IDA (9261167)
GO:0032403	protein complex binding	Molecular Function	IDA (10748068)
GO:0042542	response to hydrogen peroxide	Biological Process	IEP (17397968)