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Gene Information
Gene ID:81005
Full Name:neuronal pentraxin receptor
Organism:Rattus norvegicus (Rat)
Genetic Location:7q34
Physical Location:118023924-118041728 on NC_005106.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 23467    Symbol (Name): NPTXR (neuronal pentraxin receptor)
Ortholog Status:The human GeneID 23467 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF005099
Fold Change:2.4
Tissue:Medial prefrontal (cingulate) cortex
Gene Information
Original ID1:AF005099
Fold Change:3.2
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_030841.3NP_110468.2NC_005106.2 range: 118023924..118041728, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentIDA (10748068)
GO:0005886plasma membraneCellular ComponentIDA (10748068)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0008029pentraxin receptor activityMolecular FunctionIDA (9261167)
GO:0032403protein complex bindingMolecular FunctionIDA (10748068)
GO:0042542response to hydrogen peroxideBiological ProcessIEP (17397968)
Other Database Cross Links
NCBI Entrez Gene:81005