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Gene Information
Gene ID:24176
Symbol:Adrb2
Full Name:adrenergic receptor, beta 2
Organism:Rattus norvegicus (Rat)
Chromosome:18
Genetic Location:18q12.1
Physical Location:58174957-58176999 on NC_005117.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 154    Symbol (Name): ADRB2 (adrenergic, beta-2-, receptor, surface)
Ortholog Status:The human GeneID 154 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X17607
Fold Change:2.7
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Name:11772933
Method:Microarray
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012492.2NP_036624.2NC_005117.2 range: 58174957..58176999, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005901caveolaCellular ComponentTAS (12514203)
GO:0005624membrane fractionCellular ComponentIDA (15961389|16368719)
GO:0005624membrane fractionCellular ComponentIEA
GO:0005624membrane fractionCellular ComponentISS
GO:0005901caveolaCellular ComponentIDA (15961389)
GO:0005634nucleusCellular ComponentISS
GO:0005768endosomeCellular ComponentIDA (12932836)
GO:0005886plasma membraneCellular ComponentIDA (12932836)
GO:0005886plasma membraneCellular ComponentIEA
GO:0044424intracellular partCellular ComponentIDA (15961389)
GO:0042383sarcolemmaCellular ComponentIDA (15961389)
GO:0016324apical plasma membraneCellular ComponentIEA
GO:0043235receptor complexCellular ComponentIEA
GO:0030425dendriteCellular ComponentIDA (15682824)
GO:0030424axonCellular ComponentIDA (15682824)
GO:0043235receptor complexCellular ComponentISS
GO:0016324apical plasma membraneCellular ComponentISS
GO:0005886plasma membraneCellular ComponentIMP (15147203)
GO:0030165PDZ domain bindingMolecular FunctionTAS (10995758)
GO:0004941beta2-adrenergic receptor activityMolecular FunctionIDA (12514203)
GO:0008144drug bindingMolecular FunctionIDA (12875885)
GO:0042803protein homodimerization activityMolecular FunctionISS
GO:0042803protein homodimerization activityMolecular FunctionIEA
GO:0032403protein complex bindingMolecular FunctionIPI (11441182)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0004872receptor activityMolecular FunctionIEA
GO:0004941beta2-adrenergic receptor activityMolecular FunctionIEA
GO:0004941beta2-adrenergic receptor activityMolecular FunctionISS
GO:0051379epinephrine bindingMolecular FunctionTAS (10995758)
GO:0051380norepinephrine bindingMolecular FunctionIEA
GO:0051380norepinephrine bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0004935adrenoceptor activityMolecular FunctionIEA
GO:0043065positive regulation of apoptosisBiological ProcessIMP (15591297)
GO:0050873brown fat cell differentiationBiological ProcessIEA
GO:0050728negative regulation of inflammatory responseBiological ProcessIDA (15285793)
GO:0051927negative regulation of calcium ion transport via voltage-gated calcium channelBiological ProcessIDA (12514203)
GO:0048633positive regulation of skeletal muscle growthBiological ProcessIMP (16177600)
GO:0051930regulation of sensory perception of painBiological ProcessIMP (11569616)
GO:0050873brown fat cell differentiationBiological ProcessISS
GO:0045986negative regulation of smooth muscle contractionBiological ProcessISS
GO:0045986negative regulation of smooth muscle contractionBiological ProcessIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIEA
GO:0045909positive regulation of vasodilationBiological ProcessIDA (15351777)
GO:0045823positive regulation of heart contractionBiological ProcessIDA (15840637)
GO:0045453bone resorptionBiological ProcessISS
GO:0045453bone resorptionBiological ProcessIEA
GO:0043410positive regulation of MAPKKK cascadeBiological ProcessISS
GO:0043410positive regulation of MAPKKK cascadeBiological ProcessIEA
GO:0040015negative regulation of multicellular organism growthBiological ProcessISS
GO:0040015negative regulation of multicellular organism growthBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIDA (12514203)
GO:0006898receptor-mediated endocytosisBiological ProcessISS
GO:0006898receptor-mediated endocytosisBiological ProcessIEA
GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestinBiological ProcessISS
GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestinBiological ProcessIEA
GO:0002028regulation of sodium ion transportBiological ProcessISS
GO:0002028regulation of sodium ion transportBiological ProcessIEA
GO:0002025vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureBiological ProcessISS
GO:0002025vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureBiological ProcessIEA
GO:0002024diet induced thermogenesisBiological ProcessISS
GO:0002024diet induced thermogenesisBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007189G-protein signaling, adenylate cyclase activating pathwayBiological ProcessISS
GO:0031649heat generationBiological ProcessISS
GO:0031649heat generationBiological ProcessIEA
GO:0030501positive regulation of bone mineralizationBiological ProcessISS
GO:0030501positive regulation of bone mineralizationBiological ProcessIEA
GO:0030279negative regulation of ossificationBiological ProcessIMP (16177600)
GO:0007165signal transductionBiological ProcessIEA
GO:0009409response to coldBiological ProcessISS
GO:0009409response to coldBiological ProcessIEA
GO:0008284positive regulation of cell proliferationBiological ProcessIDA (16005083)
GO:0007190activation of adenylate cyclase activityBiological ProcessISS
GO:0007190activation of adenylate cyclase activityBiological ProcessIEA
GO:0001993regulation of systemic arterial blood pressure by norepinephrine-epinephrineBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24176
RGD:2060
Ensembl:ENSRNOG00000019217
dbSNP:Adrb2