ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

154

Symbol:

ADRB2

Full Name:

adrenergic, beta-2-, receptor, surface

Alias:

ADRB2R|ADRBR|B2AR|BAR|BETA2AR

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q31-q32

Physical Location:

148186348-148188380 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 24176 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

ADRB2

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Information

Original ID1:

ADRB2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000024.4	NP_000015.1	NC_000005.8 range: 148186348..148188380

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005768	endosome	Cellular Component	TAS (10734107)
GO:0043235	receptor complex	Cellular Component	IDA (15123695)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9228019)
GO:0005886	plasma membrane	Cellular Component	IDA (9235896)
GO:0005764	lysosome	Cellular Component	TAS (9507004)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (15123695)
GO:0051380	norepinephrine binding	Molecular Function	IDA (15123695)
GO:0005515	protein binding	Molecular Function	IPI (9560162)
GO:0004941	beta2-adrenergic receptor activity	Molecular Function	IDA (15123695)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0043410	positive regulation of MAPKKK cascade	Biological Process	IDA (15123695)
GO:0008333	endosome to lysosome transport	Biological Process	TAS (9507004)
GO:0007243	protein kinase cascade	Biological Process	TAS (10734107)
GO:0007190	activation of adenylate cyclase activity	Biological Process	IDA (15123695)
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	Biological Process	TAS (2823249)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (9924018)
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	Biological Process	TAS (10734107)
GO:0006898	receptor-mediated endocytosis	Biological Process	IDA (15123695)
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	Biological Process	IDA (15123695)
GO:0000187	activation of MAPK activity	Biological Process	TAS (9924018)