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Gene Information
Gene ID:29560
Symbol:Hif1a
Full Name:hypoxia inducible factor 1, alpha subunit
Alias:MOP1
Organism:Rattus norvegicus (Rat)
Chromosome:6
Genetic Location:6q24
Physical Location:96419023-96463890 on NC_005105.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3091    Symbol (Name): HIF1A (hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor))
Ortholog Status:The human GeneID 3091 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Y09507
Fold Change:2.4
Tissue:Amygdala
Dataset Information
Name:11772933
Method:Microarray
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_024359.1NP_077335.1NC_005105.2 range: 96419023..96463890
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentTAS (12388599)
GO:0005634nucleusCellular ComponentIDA (11313887)
GO:0005634nucleusCellular ComponentISS
GO:0005667transcription factor complexCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIDA (11237857)
GO:0005737cytoplasmCellular ComponentIEA
GO:0009434microtubule-based flagellumCellular ComponentISS
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (12675925)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0035035histone acetyltransferase bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0003704specific RNA polymerase II transcription factor activityMolecular FunctionIDA (11237857)
GO:0003702RNA polymerase II transcription factor activityMolecular FunctionTAS (9398602)
GO:0003700transcription factor activityMolecular FunctionISS
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0003690double-stranded DNA bindingMolecular FunctionTAS (9398602)
GO:0003677DNA bindingMolecular FunctionISS
GO:0046982protein heterodimerization activityMolecular FunctionISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0042981regulation of apoptosisBiological ProcessISS
GO:0042593glucose homeostasisBiological ProcessISS
GO:0042541hemoglobin biosynthetic processBiological ProcessISS
GO:0035162embryonic hemopoiesisBiological ProcessISS
GO:0051216cartilage developmentBiological ProcessISS
GO:0050790regulation of catalytic activityBiological ProcessISS
GO:0048661positive regulation of smooth muscle cell proliferationBiological ProcessIMP (16489407)
GO:0043619regulation of transcription from RNA polymerase II promoter in response to oxidative stressBiological ProcessISS
GO:0045648positive regulation of erythrocyte differentiationBiological ProcessISS
GO:0045926negative regulation of growthBiological ProcessISS
GO:0045941positive regulation of transcriptionBiological ProcessISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (11237857)
GO:0046716muscle maintenanceBiological ProcessISS
GO:0032909regulation of transforming growth factor-beta2 productionBiological ProcessISS
GO:0032869cellular response to insulin stimulusBiological ProcessIEP (16506055)
GO:0001666response to hypoxiaBiological ProcessISS
GO:0001755neural crest cell migrationBiological ProcessISS
GO:0001892embryonic placenta developmentBiological ProcessISS
GO:0001947heart loopingBiological ProcessISS
GO:0001525angiogenesisBiological ProcessISS
GO:0006089lactate metabolic processBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessTAS (12388599)
GO:0006879cellular iron ion homeostasisBiological ProcessISS
GO:0007165signal transductionBiological ProcessIEA
GO:0009749response to glucose stimulusBiological ProcessIEP (12189448)
GO:0014850response to muscle activityBiological ProcessISS
GO:0030154cell differentiationBiological ProcessISS
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathwayBiological ProcessISS
GO:0032364oxygen homeostasisBiological ProcessISS
GO:0001666response to hypoxiaBiological ProcessIDA (12388599|12675925)
Other Database Cross Links
NCBI Entrez Gene:29560
RGD:61928
Ensembl:ENSRNOG00000008292
dbSNP:Hif1a