ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Igf2

Full Name:

insulin-like growth factor 2

Alias:

IGFII|RNIGF2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q41

Physical Location:

202906623-202915230 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3481 Symbol (Name): IGF2 (insulin-like growth factor 2 (somatomedin A))

Ortholog Status:

The human GeneID 3481 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031511.1	NP_113699.1	NC_005100.2 range: 202906623..202915230, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IDA (6390212)
GO:0005615	extracellular space	Cellular Component	TAS (3023383)
GO:0005159	insulin-like growth factor receptor binding	Molecular Function	ISS
GO:0005179	hormone activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0008083	growth factor activity	Molecular Function	TAS (3023383)
GO:0008283	cell proliferation	Biological Process	TAS (3023383)
GO:0009887	organ morphogenesis	Biological Process	ISS