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Gene Information
Gene ID:24483
Full Name:insulin-like growth factor 2
Organism:Rattus norvegicus (Rat)
Genetic Location:1q41
Physical Location:202906623-202915230 on NC_005100.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3481    Symbol (Name): IGF2 (insulin-like growth factor 2 (somatomedin A))
Ortholog Status:The human GeneID 3481 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X17012
Fold Change:3.8
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031511.1NP_113699.1NC_005100.2 range: 202906623..202915230, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIDA (6390212)
GO:0005615extracellular spaceCellular ComponentTAS (3023383)
GO:0005159insulin-like growth factor receptor bindingMolecular FunctionISS
GO:0005179hormone activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0008083growth factor activityMolecular FunctionTAS (3023383)
GO:0008283cell proliferationBiological ProcessTAS (3023383)
GO:0009887organ morphogenesisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24483