ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

116590

Symbol:

Mapk1

Full Name:

mitogen activated protein kinase 1

Alias:

Erk2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

11q23

Physical Location:

85968731-86030388 on NC_005110.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5594 Symbol (Name): MAPK1 (mitogen-activated protein kinase 1)

Ortholog Status:

The human GeneID 5594 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M64300
Fold Change:		5.6
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053842.1	NP_446294.1	NC_005110.2 range: 85968731..86030388, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005625	soluble fraction	Cellular Component	IDA (15027896)
GO:0005626	insoluble fraction	Cellular Component	IDA (9779826)
GO:0005634	nucleus	Cellular Component	IDA (17150373)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IDA (9779826)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	TAS (11687663)
GO:0004707	MAP kinase activity	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (15027896)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IDA (15027896)
GO:0004707	MAP kinase activity	Molecular Function	TAS (9779826)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	ISS
GO:0001784	phosphotyrosine binding	Molecular Function	ISS
GO:0004672	protein kinase activity	Molecular Function	ISS
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IC (15027896)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004707	MAP kinase activity	Molecular Function	IDA (15027896)
GO:0004707	MAP kinase activity	Molecular Function	IEA
GO:0045941	positive regulation of transcription	Biological Process	IEP (12097495)
GO:0045596	negative regulation of cell differentiation	Biological Process	ISS
GO:0019233	sensory perception of pain	Biological Process	IMP
GO:0019858	cytosine metabolic process	Biological Process	ISS
GO:0030335	positive regulation of cell migration	Biological Process	IEP (15917991)
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	ISS
GO:0032496	response to lipopolysaccharide	Biological Process	ISS
GO:0042221	response to chemical stimulus	Biological Process	IDA (12487375)
GO:0043627	response to estrogen stimulus	Biological Process	IDA (11751611)
GO:0045727	positive regulation of translation	Biological Process	IMP (15027896)
GO:0043330	response to exogenous dsRNA	Biological Process	ISS
GO:0009887	organ morphogenesis	Biological Process	ISS
GO:0000189	nuclear translocation of MAPK	Biological Process	IDA (12097495)
GO:0000165	MAPKKK cascade	Biological Process	IMP (17310240)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (15027896)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (9779826)
GO:0006974	response to DNA damage stimulus	Biological Process	ISS
GO:0007049	cell cycle	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IDA (11714707)
GO:0007242	intracellular signaling cascade	Biological Process	IDA (12072413)
GO:0007243	protein kinase cascade	Biological Process	TAS (9779826)
GO:0008284	positive regulation of cell proliferation	Biological Process	IEP (15583728)
GO:0000165	MAPKKK cascade	Biological Process	ISS