ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MAPK1

Full Name:

mitogen-activated protein kinase 1

Alias:

ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q11.2|22q11.21

Physical Location:

20443945-20551969 on NC_000022.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 116590 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

MAPK1

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Information

Original ID1:

MAPK1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (10066798\|10878576)
GO:0005654	nucleoplasm	Cellular Component	EXP (9687510\|16456541\|16626623\|17322878)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (9632734\|16286470\|16291755)
GO:0004707	MAP kinase activity	Molecular Function	TAS (10706854)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	EXP (16626623)
GO:0007268	synaptic transmission	Biological Process	TAS (10051431)
GO:0007265	Ras protein signal transduction	Biological Process	EXP (11520933)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006950	response to stress	Biological Process	TAS (10958679)
GO:0006935	chemotaxis	Biological Process	TAS (10706854)
GO:0006917	induction of apoptosis	Biological Process	TAS (10958679)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA