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Gene Information
Gene ID:170851
Full Name:mitogen activated protein kinase kinase 1
Organism:Rattus norvegicus (Rat)
Genetic Location:8q24
Physical Location:68379073-68451556 on NC_005107.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5604    Symbol (Name): MAP2K1 (mitogen-activated protein kinase kinase 1)
Ortholog Status:The human GeneID 5604 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L04485
Fold Change:2.3
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031643.3NP_113831.1NC_005107.2 range: 68379073..68451556, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentIDA (9779826)
GO:0005794Golgi apparatusCellular ComponentIDA (12695496)
GO:0016740transferase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIDA (12401521)
GO:0004728receptor signaling protein tyrosine phosphatase activityMolecular FunctionISS
GO:0004713protein-tyrosine kinase activityMolecular FunctionIEA
GO:0004708MAP kinase kinase activityMolecular FunctionTAS (9779826)
GO:0004708MAP kinase kinase activityMolecular FunctionISS
GO:0004708MAP kinase kinase activityMolecular FunctionIMP (17310240)
GO:0004708MAP kinase kinase activityMolecular FunctionIEA
GO:0004708MAP kinase kinase activityMolecular FunctionIDA (7624324)
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0030182neuron differentiationBiological ProcessIEA
GO:0030182neuron differentiationBiological ProcessISS
GO:0030216keratinocyte differentiationBiological ProcessIEA
GO:0030216keratinocyte differentiationBiological ProcessISS
GO:0043406positive regulation of MAP kinase activityBiological ProcessISS
GO:0008283cell proliferationBiological ProcessIDA (16481589)
GO:0007243protein kinase cascadeBiological ProcessTAS (9779826)
GO:0007067mitosisBiological ProcessIDA (12695496)
GO:0006979response to oxidative stressBiological ProcessIDA (16481589)
GO:0006468protein amino acid phosphorylationBiological ProcessTAS (9779826)
GO:0006468protein amino acid phosphorylationBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0000165MAPKKK cascadeBiological ProcessIMP (17310240)
GO:0051384response to glucocorticoid stimulusBiological ProcessIDA (11872750)
Other Database Cross Links
NCBI Entrez Gene:170851