ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

170851

Symbol:

Map2k1

Full Name:

mitogen activated protein kinase kinase 1

Alias:

Mek1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

8q24

Physical Location:

68379073-68451556 on NC_005107.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5604 Symbol (Name): MAP2K1 (mitogen-activated protein kinase kinase 1)

Ortholog Status:

The human GeneID 5604 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L04485
Fold Change:		2.3
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031643.3	NP_113831.1	NC_005107.2 range: 68379073..68451556, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	IDA (9779826)
GO:0005794	Golgi apparatus	Cellular Component	IDA (12695496)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IDA (12401521)
GO:0004728	receptor signaling protein tyrosine phosphatase activity	Molecular Function	ISS
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004708	MAP kinase kinase activity	Molecular Function	TAS (9779826)
GO:0004708	MAP kinase kinase activity	Molecular Function	ISS
GO:0004708	MAP kinase kinase activity	Molecular Function	IMP (17310240)
GO:0004708	MAP kinase kinase activity	Molecular Function	IEA
GO:0004708	MAP kinase kinase activity	Molecular Function	IDA (7624324)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0030182	neuron differentiation	Biological Process	IEA
GO:0030182	neuron differentiation	Biological Process	ISS
GO:0030216	keratinocyte differentiation	Biological Process	IEA
GO:0030216	keratinocyte differentiation	Biological Process	ISS
GO:0043406	positive regulation of MAP kinase activity	Biological Process	ISS
GO:0008283	cell proliferation	Biological Process	IDA (16481589)
GO:0007243	protein kinase cascade	Biological Process	TAS (9779826)
GO:0007067	mitosis	Biological Process	IDA (12695496)
GO:0006979	response to oxidative stress	Biological Process	IDA (16481589)
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (9779826)
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0000165	MAPKKK cascade	Biological Process	IMP (17310240)
GO:0051384	response to glucocorticoid stimulus	Biological Process	IDA (11872750)