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Gene Information
Gene ID:25388
Full Name:arrestin, beta 2
Organism:Rattus norvegicus (Rat)
Genetic Location:10q24
Physical Location:57276372-57284170 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 409    Symbol (Name): ARRB2 (arrestin, beta 2)
Ortholog Status:The human GeneID 409 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M91590
Fold Change:2.7
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012911.1NP_037043.1NC_005109.2 range: 57276372..57284170
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0045211postsynaptic membraneCellular ComponentIDA (157224|1517224)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005622intracellularCellular ComponentISS
GO:0019904protein domain specific bindingMolecular FunctionIPI (12890920)
GO:0030276clathrin bindingMolecular FunctionTAS (11823056)
GO:0001664G-protein-coupled receptor bindingMolecular FunctionTAS (11823056)
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (15361545)
GO:0030817regulation of cAMP biosynthetic processBiological ProcessTAS (12399592)
GO:0030820regulation of cAMP catabolic processBiological ProcessTAS (12399592)
GO:0008277regulation of G-protein coupled receptor protein signaling pathwayBiological ProcessISS
GO:0008277regulation of G-protein coupled receptor protein signaling pathwayBiological ProcessIDA (1517224)
GO:0007600sensory perceptionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIDA (157224)
GO:0007165signal transductionBiological ProcessIEA
GO:0006897endocytosisBiological ProcessIDA (12600992)
GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestinBiological ProcessTAS (11823056)
GO:0001932regulation of protein amino acid phosphorylationBiological ProcessISS
GO:0050896response to stimulusBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:25388