ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Arrb2

Full Name:

arrestin, beta 2

Alias:

BARRES|MGC105502

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q24

Physical Location:

57276372-57284170 on NC_005109.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 409 Symbol (Name): ARRB2 (arrestin, beta 2)

Ortholog Status:

The human GeneID 409 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012911.1	NP_037043.1	NC_005109.2 range: 57276372..57284170

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0045211	postsynaptic membrane	Cellular Component	IDA (157224\|1517224)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	ISS
GO:0019904	protein domain specific binding	Molecular Function	IPI (12890920)
GO:0030276	clathrin binding	Molecular Function	TAS (11823056)
GO:0001664	G-protein-coupled receptor binding	Molecular Function	TAS (11823056)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI (15361545)
GO:0030817	regulation of cAMP biosynthetic process	Biological Process	TAS (12399592)
GO:0030820	regulation of cAMP catabolic process	Biological Process	TAS (12399592)
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	Biological Process	ISS
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	Biological Process	IDA (1517224)
GO:0007600	sensory perception	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IDA (157224)
GO:0007165	signal transduction	Biological Process	IEA
GO:0006897	endocytosis	Biological Process	IDA (12600992)
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	Biological Process	TAS (11823056)
GO:0001932	regulation of protein amino acid phosphorylation	Biological Process	ISS
GO:0050896	response to stimulus	Biological Process	IEA