Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:409
Full Name:arrestin, beta 2
Organism:Homo sapiens (Human)
Genetic Location:17p13
Physical Location:4560537-4571543 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has Rat: 25388 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:ARRB2
Dataset Information
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:ARRB2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004313.3NP_004304.1NC_000017.9 range: 4560537..4571543
NM_199004.1NP_945355.1NC_000017.9 range: 4560537..4571543
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentTAS (9346876)
GO:0005886plasma membraneCellular ComponentTAS (9346876)
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0007165signal transductionBiological ProcessIEA
GO:0007600sensory perceptionBiological ProcessIEA
GO:0050896response to stimulusBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:409
HuGE Navigator:409