Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:29483
Full Name:solute carrier family 1 (glial high affinity glutamate transporter), member 3
Organism:Rattus norvegicus (Rat)
Genetic Location:2q16
Physical Location:58270235-58347612 on NC_005101.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6507    Symbol (Name): SLC1A3 (solute carrier family 1 (glial high affinity glutamate transporter), member 3)
Ortholog Status:The human GeneID 6507 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X63744
Fold Change:5.7
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019225.1NP_062098.1NC_005101.2 range: 58270235..58347612, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045202synapseCellular ComponentIDA (11950769)
GO:0043197dendritic spineCellular ComponentIDA (11950769)
GO:0043025cell somaCellular ComponentISS
GO:0005624membrane fractionCellular ComponentIDA (10899959)
GO:0005743mitochondrial inner membraneCellular ComponentIDA (15242733)
GO:0005886plasma membraneCellular ComponentIDA (9786982)
GO:0043005neuron projectionCellular ComponentIDA (9786982)
GO:0042995cell projectionCellular ComponentISS
GO:0005313L-glutamate transmembrane transporter activityMolecular FunctionIDA (15242733)
GO:0005314high-affinity glutamate transmembrane transporter activityMolecular FunctionIMP (10899959)
GO:0005313L-glutamate transmembrane transporter activityMolecular FunctionTAS (11950769)
GO:0015813L-glutamate transportBiological ProcessIMP (10899959)
GO:0006836neurotransmitter transportBiological ProcessTAS (11950769)
GO:0043490malate-aspartate shuttleBiological ProcessIDA (15242733)
GO:0015813L-glutamate transportBiological ProcessIDA (15242733)
Other Database Cross Links
NCBI Entrez Gene:29483