ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc1a3

Full Name:

solute carrier family 1 (glial high affinity glutamate transporter), member 3

Alias:

EAAT1|GLAST|GluT-1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q16

Physical Location:

58270235-58347612 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6507 Symbol (Name): SLC1A3 (solute carrier family 1 (glial high affinity glutamate transporter), member 3)

Ortholog Status:

The human GeneID 6507 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X63744
Fold Change:		5.7
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019225.1	NP_062098.1	NC_005101.2 range: 58270235..58347612, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045202	synapse	Cellular Component	IDA (11950769)
GO:0043197	dendritic spine	Cellular Component	IDA (11950769)
GO:0043025	cell soma	Cellular Component	ISS
GO:0005624	membrane fraction	Cellular Component	IDA (10899959)
GO:0005743	mitochondrial inner membrane	Cellular Component	IDA (15242733)
GO:0005886	plasma membrane	Cellular Component	IDA (9786982)
GO:0043005	neuron projection	Cellular Component	IDA (9786982)
GO:0042995	cell projection	Cellular Component	ISS
GO:0005313	L-glutamate transmembrane transporter activity	Molecular Function	IDA (15242733)
GO:0005314	high-affinity glutamate transmembrane transporter activity	Molecular Function	IMP (10899959)
GO:0005313	L-glutamate transmembrane transporter activity	Molecular Function	TAS (11950769)
GO:0015813	L-glutamate transport	Biological Process	IMP (10899959)
GO:0006836	neurotransmitter transport	Biological Process	TAS (11950769)
GO:0043490	malate-aspartate shuttle	Biological Process	IDA (15242733)
GO:0015813	L-glutamate transport	Biological Process	IDA (15242733)