ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC1A3

Full Name:

solute carrier family 1 (glial high affinity glutamate transporter), member 3

Alias:

EA6|EAAT1|FLJ25094|GLAST|GLAST1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5p13

Physical Location:

36642445-36724190 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 29483 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004172.4	NP_004163.3	NC_000005.8 range: 36642445..36724190

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	TAS (7521911)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0017153	sodium:dicarboxylate symporter activity	Molecular Function	IEA
GO:0005313	L-glutamate transmembrane transporter activity	Molecular Function	TAS (7521911)
GO:0015293	symporter activity	Molecular Function	IEA
GO:0015813	L-glutamate transport	Biological Process	TAS (7521911)
GO:0007268	synaptic transmission	Biological Process	TAS (7521911)
GO:0006835	dicarboxylic acid transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0001504	neurotransmitter uptake	Biological Process	TAS (8647279)