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Gene Information
Gene ID:29627
Full Name:glutamate receptor, ionotropic, AMPA2
Organism:Rattus norvegicus (Rat)
Genetic Location:2q33
Physical Location:172266137-172385284 on NC_005101.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2891    Symbol (Name): GRIA2 (glutamate receptor, ionotropic, AMPA 2)
Ortholog Status:The human GeneID 2891 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M38061
Fold Change:2.4
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Information
Original ID1:Gria2
Fold Change:-1.16
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017261.2NP_058957.1NC_005101.2 range: 172266137..172385284, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043234protein complexCellular ComponentIDA (17329210)
GO:0030672synaptic vesicle membraneCellular ComponentIDA (12554656)
GO:0032279asymmetric synapseCellular ComponentIDA (12077196)
GO:0032839dendrite cytoplasmCellular ComponentIDA (17207780)
GO:0042734presynaptic membraneCellular ComponentIDA (12554656)
GO:0043025cell somaCellular ComponentIDA (12077196|15844209)
GO:0043195terminal buttonCellular ComponentIDA (15844209)
GO:0043197dendritic spineCellular ComponentIDA (12077196|17207780)
GO:0043198dendritic shaftCellular ComponentIDA (12077196)
GO:0043204perikaryonCellular ComponentIDA (15844209)
GO:0030426growth coneCellular ComponentIDA (12554656)
GO:0030425dendriteCellular ComponentIDA (15844209)
GO:0005624membrane fractionCellular ComponentISS
GO:0014069postsynaptic densityCellular ComponentIDA (12077196)
GO:0019901protein kinase bindingMolecular FunctionIPI (17329210)
GO:0005515protein bindingMolecular FunctionISS
GO:0005234extracellular-glutamate-gated ion channel activityMolecular FunctionISS
GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityMolecular FunctionTAS (12554656)
GO:0004970ionotropic glutamate receptor activityMolecular FunctionTAS (12554656)
GO:0004970ionotropic glutamate receptor activityMolecular FunctionISS
GO:0007268synaptic transmissionBiological ProcessISS
GO:0007268synaptic transmissionBiological ProcessIPI (12554656)
Other Database Cross Links
NCBI Entrez Gene:29627