ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

24708

Symbol:

Rb1

Full Name:

retinoblastoma 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

15q12

Physical Location:

53828880-53962098 on NC_005114.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5925 Symbol (Name): RB1 (retinoblastoma 1 (including osteosarcoma))

Ortholog Status:

The human GeneID 5925 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D25233
Fold Change:		3.5
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_344434.3	XP_344435.3	NC_005114.2 range: 53828880..53962098, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005667	transcription factor complex	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (10725332)
GO:0005667	transcription factor complex	Cellular Component	ISS
GO:0005819	spindle	Cellular Component	IEA
GO:0005819	spindle	Cellular Component	ISS
GO:0016605	PML body	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	ISS
GO:0016564	transcription repressor activity	Molecular Function	IEA
GO:0008134	transcription factor binding	Molecular Function	ISS
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI (12063292)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0019900	kinase binding	Molecular Function	ISS
GO:0008134	transcription factor binding	Molecular Function	IEA
GO:0045651	positive regulation of macrophage differentiation	Biological Process	IEA
GO:0045651	positive regulation of macrophage differentiation	Biological Process	ISS
GO:0045786	negative regulation of cell cycle	Biological Process	IEA
GO:0043550	regulation of lipid kinase activity	Biological Process	ISS
GO:0045786	negative regulation of cell cycle	Biological Process	ISS
GO:0051726	regulation of cell cycle	Biological Process	ISS
GO:0051301	cell division	Biological Process	ISS
GO:0051301	cell division	Biological Process	IEA
GO:0051146	striated muscle cell differentiation	Biological Process	ISS
GO:0051146	striated muscle cell differentiation	Biological Process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0043353	enucleate erythrocyte differentiation	Biological Process	ISS
GO:0043353	enucleate erythrocyte differentiation	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006469	negative regulation of protein kinase activity	Biological Process	ISS
GO:0007050	cell cycle arrest	Biological Process	IEA
GO:0007050	cell cycle arrest	Biological Process	ISS
GO:0008285	negative regulation of cell proliferation	Biological Process	IEA
GO:0008285	negative regulation of cell proliferation	Biological Process	ISS
GO:0016568	chromatin modification	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	ISS