ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cnr1

Full Name:

cannabinoid receptor 1 (brain)

Alias:

SKR6R

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q21

Physical Location:

50427172-50445470 on NC_005104.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1268 Symbol (Name): CNR1 (cannabinoid receptor 1 (brain))

Ortholog Status:

The human GeneID 1268 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X55812
Fold Change:		2.6
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012784.3	NP_036916.1	NC_005104.2 range: 50427172..50445470

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IMP (2165569)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004949	cannabinoid receptor activity	Molecular Function	IEA
GO:0004949	cannabinoid receptor activity	Molecular Function	IMP (2165569\|17110038)
GO:0008144	drug binding	Molecular Function	IMP (17110038)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IMP (2165569\|17110038)