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Gene Information
Gene ID:25248
Full Name:cannabinoid receptor 1 (brain)
Organism:Rattus norvegicus (Rat)
Genetic Location:5q21
Physical Location:50427172-50445470 on NC_005104.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1268    Symbol (Name): CNR1 (cannabinoid receptor 1 (brain))
Ortholog Status:The human GeneID 1268 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X55812
Fold Change:2.6
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012784.3NP_036916.1NC_005104.2 range: 50427172..50445470
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIMP (2165569)
GO:0016021integral to membraneCellular ComponentIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0004949cannabinoid receptor activityMolecular FunctionIEA
GO:0004949cannabinoid receptor activityMolecular FunctionIMP (2165569|17110038)
GO:0008144drug bindingMolecular FunctionIMP (17110038)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIMP (2165569|17110038)
Other Database Cross Links
NCBI Entrez Gene:25248