ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mapre3

Full Name:

microtubule-associated protein, RP/EB family, member 3

Alias:

AI790651|EB2|EB3

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 B1

Physical Location:

31117128-31168478 on NC_000071.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 22924 Symbol (Name): MAPRE3 (microtubule-associated protein, RP/EB family, member 3)

Ortholog Status:

The human GeneID 22924 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mapre3
Original ID2:		AV091649

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_133350.1	NP_579928.1	NC_000071.5 range: 31117128..31168478

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005874	microtubule	Cellular Component	IEA
GO:0030496	midbody	Cellular Component	IDA (17310996)
GO:0005515	protein binding	Molecular Function	IPI (17310996)
GO:0008017	microtubule binding	Molecular Function	RCA (12466851)
GO:0043193	positive regulation of gene-specific transcription	Biological Process	IMP (17310996)
GO:0007067	mitosis	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0051301	cell division	Biological Process	IEA