| Gene Information |
| Gene ID: | | 10085 |
| Symbol: | | EDIL3 |
| Full Name: | | EGF-like repeats and discoidin I-like domains 3 |
| Alias: | | DEL1|MGC26287 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 5 |
| Genetic Location: | | 5q14 |
| Physical Location: | | 83273881-83716366 on NC_000005.8, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AI677769 | | Fold Change: | | -1.4, -1.4 | | Note: | | Differential Expression on the cDNA array (two fold changes are from two case groups) |
| | Dataset Information | | Name: | | 11141048 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed | | Summary: | | RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics. |
| | Gene Information | | Original ID1: | | Hs.482730 | | Note: | | "Class II, down-regulated gene" |
| | Dataset Information | | Name: | | 16292326 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed | | Summary: | | In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0005178 | integrin binding | Molecular Function | TAS (9420328) | |
| GO:0005509 | calcium ion binding | Molecular Function | IEA | |
| GO:0005515 | protein binding | Molecular Function | IEA | |
| GO:0007155 | cell adhesion | Biological Process | IEA | |
| GO:0007275 | multicellular organismal development | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 10085 |
| HGNC: | | 3173 |
| Ensembl: | | ENSG00000164176 |
| MIM: | | 606018 |
| HPRD: | | 09350 |
| HuGE Navigator: | | 10085 |
| dbSNP: | | EDIL3 |
| GeneCard: | | EDIL3 |
| AceView: | | EDIL3 |
