ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LRPPRC

Full Name:

leucine-rich PPR-motif containing

Alias:

CLONE-23970|GP130|LRP130|LSFC

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2p21

Physical Location:

43968390-44076647 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.368084
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_133259.3	NP_573566.2	NC_000002.10 range: 43968390..44076647, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000794	condensed nuclear chromosome	Cellular Component	IDA (12762840)
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA (12762840)
GO:0005856	cytoskeleton	Cellular Component	IDA (12762840)
GO:0005739	mitochondrion	Cellular Component	IDA (12832482)
GO:0005640	nuclear outer membrane	Cellular Component	IEA
GO:0005637	nuclear inner membrane	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (12832482)
GO:0016020	membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (17050673\|17353931)
GO:0003723	RNA binding	Molecular Function	NAS (12832482)
GO:0051015	actin filament binding	Molecular Function	IDA (12762840)
GO:0048487	beta-tubulin binding	Molecular Function	IDA (12762840)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0008017	microtubule binding	Molecular Function	TAS (12762840)
GO:0047497	mitochondrion transport along microtubule	Biological Process	TAS (12762840)
GO:0006810	transport	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0051028	mRNA transport	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000138095

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: