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Gene Information
Gene ID:10128
Full Name:leucine-rich PPR-motif containing
Organism:Homo sapiens (Human)
Genetic Location:2p21
Physical Location:43968390-44076647 on NC_000002.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.368084
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_133259.3NP_573566.2NC_000002.10 range: 43968390..44076647, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000794condensed nuclear chromosomeCellular ComponentIDA (12762840)
GO:0048471perinuclear region of cytoplasmCellular ComponentIDA (12762840)
GO:0005856cytoskeletonCellular ComponentIDA (12762840)
GO:0005739mitochondrionCellular ComponentIDA (12832482)
GO:0005640nuclear outer membraneCellular ComponentIEA
GO:0005637nuclear inner membraneCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (12832482)
GO:0016020membraneCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIPI (17050673|17353931)
GO:0003723RNA bindingMolecular FunctionNAS (12832482)
GO:0051015actin filament bindingMolecular FunctionIDA (12762840)
GO:0048487beta-tubulin bindingMolecular FunctionIDA (12762840)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0008017microtubule bindingMolecular FunctionTAS (12762840)
GO:0047497mitochondrion transport along microtubuleBiological ProcessTAS (12762840)
GO:0006810transportBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0051028mRNA transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:10128
HuGE Navigator:10128