ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ABI2

Full Name:

abl interactor 2

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33

Physical Location:

203901247-204005136 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.471156
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

ABI2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005759.4	NP_005750.4	NC_000002.10 range: 203901247..204005136

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030175	filopodium	Cellular Component	NAS (11516653)
GO:0030027	lamellipodium	Cellular Component	NAS (11516653)
GO:0005737	cytoplasm	Cellular Component	NAS (8649853)
GO:0005737	cytoplasm	Cellular Component	TAS (8649853)
GO:0005829	cytosol	Cellular Component	IDA (17101133)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0019900	kinase binding	Molecular Function	NAS (8649853)
GO:0017124	SH3 domain binding	Molecular Function	TAS (8649853)
GO:0008093	cytoskeletal adaptor activity	Molecular Function	TAS (12011975)
GO:0005070	SH3/SH2 adaptor activity	Molecular Function	TAS (7590236)
GO:0003677	DNA binding	Molecular Function	TAS (7590236)
GO:0003674	molecular_function	Molecular Function	ND
GO:0008150	biological_process	Biological Process	ND
GO:0008154	actin polymerization and/or depolymerization	Biological Process	NAS (11516653)
GO:0016477	cell migration	Biological Process	TAS (12011975)
GO:0007010	cytoskeleton organization and biogenesis	Biological Process	TAS (12011975)
GO:0018108	peptidyl-tyrosine phosphorylation	Biological Process	IDA (17101133)