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Gene Information
Gene ID:10152
Full Name:abl interactor 2
Organism:Homo sapiens (Human)
Genetic Location:2q33
Physical Location:203901247-204005136 on NC_000002.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.471156
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:ABI2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D2S117  195326948
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005759.4NP_005750.4NC_000002.10 range: 203901247..204005136
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030175filopodiumCellular ComponentNAS (11516653)
GO:0030027lamellipodiumCellular ComponentNAS (11516653)
GO:0005737cytoplasmCellular ComponentNAS (8649853)
GO:0005737cytoplasmCellular ComponentTAS (8649853)
GO:0005829cytosolCellular ComponentIDA (17101133)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0019900kinase bindingMolecular FunctionNAS (8649853)
GO:0017124SH3 domain bindingMolecular FunctionTAS (8649853)
GO:0008093cytoskeletal adaptor activityMolecular FunctionTAS (12011975)
GO:0005070SH3/SH2 adaptor activityMolecular FunctionTAS (7590236)
GO:0003677DNA bindingMolecular FunctionTAS (7590236)
GO:0003674molecular_functionMolecular FunctionND
GO:0008150biological_processBiological ProcessND
GO:0008154actin polymerization and/or depolymerizationBiological ProcessNAS (11516653)
GO:0016477cell migrationBiological ProcessTAS (12011975)
GO:0007010cytoskeleton organization and biogenesisBiological ProcessTAS (12011975)
GO:0018108peptidyl-tyrosine phosphorylationBiological ProcessIDA (17101133)
Other Database Cross Links
NCBI Entrez Gene:10152
HuGE Navigator:10152