ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MBOAT5

Full Name:

membrane bound O-acyltransferase domain containing 5

Alias:

C3F|LPCAT3|OACT5|nessy

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12p13

Physical Location:

6955607-6996102 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 40093 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005768.5	NP_005759.4	NC_000012.10 range: 6955607..6996102, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0008415	acyltransferase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	Molecular Function	IEA
GO:0008654	phospholipid biosynthetic process	Biological Process	IEA