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Gene Information
Gene ID:40093
Organism:Drosophila melanogaster (Fly)
Genetic Location:76A3-76A3
Physical Location:19250510-19253778 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10162    Symbol (Name): MBOAT5 (membrane bound O-acyltransferase domain containing 5)
Ortholog Status:The human GeneID 10162 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:nes
P Value:4.86E-02
Note:Slow down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079433.2NP_524157.2NT_037436.3 range: 19250510..19253778, complement
NM_168788.2NP_730390.1NT_037436.3 range: 19250510..19253778, complement
NM_176349.1NP_788527.1NT_037436.3 range: 19250510..19253778, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentNAS
GO:0003674molecular_functionMolecular FunctionND
GO:0008150biological_processBiological ProcessND
Other Database Cross Links
NCBI Entrez Gene:40093