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Gene Information
Gene ID:1022
Full Name:cyclin-dependent kinase 7
Organism:Homo sapiens (Human)
Genetic Location:5q12.1
Physical Location:68566470-68609005 on NC_000005.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.184298
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Linkage Dataset
MarkerLODP valueLocation (bp)
D5S647  66282906
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001799.3NP_001790.1NC_000005.8 range: 68566470..68609005
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005654nucleoplasmCellular ComponentEXP (1939271|2449431|7629134|7799941|8946909|9512541|9582279|9790902|10214908|11313499|12393749|12646563|)
GO:0005634nucleusCellular ComponentIDA (16109376)
GO:0008353RNA polymerase subunit kinase activityMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0008022protein C-terminus bindingMolecular FunctionIPI (10801852)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0004693cyclin-dependent protein kinase activityMolecular FunctionTAS (8208544)
GO:0003713transcription coactivator activityMolecular FunctionNAS (15572661)
GO:0050681androgen receptor bindingMolecular FunctionNAS (15572661)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (8692841)
GO:0030521androgen receptor signaling pathwayBiological ProcessNAS (15572661)
GO:0008283cell proliferationBiological ProcessTAS (7533895)
GO:0000079regulation of cyclin-dependent protein kinase activityBiological ProcessTAS (7533895)
GO:0007049cell cycleBiological ProcessIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0006368RNA elongation from RNA polymerase II promoterBiological ProcessEXP (9405375)
GO:0006367transcription initiation from RNA polymerase II promoterBiological ProcessTAS (7533895)
GO:0006367transcription initiation from RNA polymerase II promoterBiological ProcessEXP (8946909)
GO:0006350transcriptionBiological ProcessIEA
GO:0006281DNA repairBiological ProcessIEA
GO:0000718nucleotide-excision repair, DNA damage removalBiological ProcessEXP (10583946)
GO:0051301cell divisionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:1022
HuGE Navigator:1022