ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

1022

Symbol:

CDK7

Full Name:

cyclin-dependent kinase 7

Alias:

CAK1|CDKN7|MO15|STK1|p39MO15

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q12.1

Physical Location:

68566470-68609005 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.184298
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D5S647

66282906

Region:		66282906-76193808
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001799.3	NP_001790.1	NC_000005.8 range: 68566470..68609005

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	EXP (1939271\|2449431\|7629134\|7799941\|8946909\|9512541\|9582279\|9790902\|10214908\|11313499\|12393749\|12646563\|)
GO:0005634	nucleus	Cellular Component	IDA (16109376)
GO:0008353	RNA polymerase subunit kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008022	protein C-terminus binding	Molecular Function	IPI (10801852)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004693	cyclin-dependent protein kinase activity	Molecular Function	TAS (8208544)
GO:0003713	transcription coactivator activity	Molecular Function	NAS (15572661)
GO:0050681	androgen receptor binding	Molecular Function	NAS (15572661)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (8692841)
GO:0030521	androgen receptor signaling pathway	Biological Process	NAS (15572661)
GO:0008283	cell proliferation	Biological Process	TAS (7533895)
GO:0000079	regulation of cyclin-dependent protein kinase activity	Biological Process	TAS (7533895)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006368	RNA elongation from RNA polymerase II promoter	Biological Process	EXP (9405375)
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	TAS (7533895)
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	EXP (8946909)
GO:0006350	transcription	Biological Process	IEA
GO:0006281	DNA repair	Biological Process	IEA
GO:0000718	nucleotide-excision repair, DNA damage removal	Biological Process	EXP (10583946)
GO:0051301	cell division	Biological Process	IEA