ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SPRY1

Full Name:

sprouty homolog 1, antagonist of FGF signaling (Drosophila)

Alias:

hSPRY1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q28.1

Physical Location:

124537405-124544359 on NC_000004.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.436944
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	NAS
GO:0005829	cytosol	Cellular Component	EXP (12593796)
GO:0005886	plasma membrane	Cellular Component	EXP (15962011)
GO:0030027	lamellipodium	Cellular Component	NAS
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0009966	regulation of signal transduction	Biological Process	IEA