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Gene Information
Gene ID:1027
Full Name:cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Organism:Homo sapiens (Human)
Genetic Location:12p13.1-p12
Physical Location:12761575-12766569 on NC_000012.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.238990
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004064.2NP_004055.1NC_000012.10 range: 12761575..12766569
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (12244303)
GO:0005737cytoplasmCellular ComponentIDA (12093740)
GO:0005634nucleusCellular ComponentIDA (12093740)
GO:0005515protein bindingMolecular FunctionIPI (8756624|9106657|9840943|12082530|15057270|15652749|15890360|17254966|17254967)
GO:0005072transforming growth factor beta receptor, cytoplasmic mediator activityMolecular FunctionTAS (8033212)
GO:0004861cyclin-dependent protein kinase inhibitor activityMolecular FunctionTAS (10918569)
GO:0004860protein kinase inhibitor activityMolecular FunctionIEA
GO:0042326negative regulation of phosphorylationBiological ProcessIDA (10208428)
GO:0030308negative regulation of cell growthBiological ProcessIDA (10208428)
GO:0008285negative regulation of cell proliferationBiological ProcessTAS (8033212)
GO:0007050cell cycle arrestBiological ProcessIMP (12093740)
GO:0007049cell cycleBiological ProcessIEA
GO:0006917induction of apoptosisBiological ProcessIDA (10208428)
GO:0000079regulation of cyclin-dependent protein kinase activityBiological ProcessTAS (8033212)
GO:0000082G1/S transition of mitotic cell cycleBiological ProcessIDA (10208428)
GO:0048102autophagic cell deathBiological ProcessIDA (12698196)
Other Database Cross Links
NCBI Entrez Gene:1027
HuGE Navigator:1027