ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CDKN1B

Full Name:

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Alias:

CDKN4|KIP1|MEN1B|MEN4|P27KIP1

Organism:

Homo sapiens (Human)

Chromosome:

12

Genetic Location:

12p13.1-p12

Physical Location:

12761575-12766569 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.238990
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004064.2	NP_004055.1	NC_000012.10 range: 12761575..12766569

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (12244303)
GO:0005737	cytoplasm	Cellular Component	IDA (12093740)
GO:0005634	nucleus	Cellular Component	IDA (12093740)
GO:0005515	protein binding	Molecular Function	IPI (8756624\|9106657\|9840943\|12082530\|15057270\|15652749\|15890360\|17254966\|17254967)
GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity	Molecular Function	TAS (8033212)
GO:0004861	cyclin-dependent protein kinase inhibitor activity	Molecular Function	TAS (10918569)
GO:0004860	protein kinase inhibitor activity	Molecular Function	IEA
GO:0042326	negative regulation of phosphorylation	Biological Process	IDA (10208428)
GO:0030308	negative regulation of cell growth	Biological Process	IDA (10208428)
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS (8033212)
GO:0007050	cell cycle arrest	Biological Process	IMP (12093740)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006917	induction of apoptosis	Biological Process	IDA (10208428)
GO:0000079	regulation of cyclin-dependent protein kinase activity	Biological Process	TAS (8033212)
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IDA (10208428)
GO:0048102	autophagic cell death	Biological Process	IDA (12698196)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000111276

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: