ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

1029

Symbol:

CDKN2A

Full Name:

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Alias:

ARF|CDK4I|CDKN2|CMM2|INK4|INK4a|MLM|MTS1|TP16|p14|p14ARF|p16|p16INK4|p16INK4a|p19

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9p21

Physical Location:

21957750-21984489 on NC_000009.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12578 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CDKN2A

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000077.3	NP_000068.1	NC_000009.10 range: 21957750..21984489, complement
NM_058195.2	NP_478102.1	NC_000009.10 range: 21957750..21984489, complement
NM_058197.3	NP_478104.2	NC_000009.10 range: 21957750..21984489, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (16243918)
GO:0005730	nucleolus	Cellular Component	IDA (17110379)
GO:0005654	nucleoplasm	Cellular Component	IDA (17110379)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (16243918)
GO:0019901	protein kinase binding	Molecular Function	IPI (8259215)
GO:0051059	NF-kappaB binding	Molecular Function	IDA (10353611)
GO:0005515	protein binding	Molecular Function	IPI (11278317\|12740913\|15989956\|17274640\|17909018)
GO:0004861	cyclin-dependent protein kinase inhibitor activity	Molecular Function	IDA (8259215)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (16243918)
GO:0008637	apoptotic mitochondrial changes	Biological Process	IMP (12082630)
GO:0010149	senescence	Biological Process	IMP (14720514\|14966292)
GO:0010389	regulation of G2/M transition of mitotic cell cycle	Biological Process	IMP (15582998)
GO:0045786	negative regulation of cell cycle	Biological Process	IEA
GO:0030308	negative regulation of cell growth	Biological Process	IDA (10208428)
GO:0032088	inhibition of NF-kappaB transcription factor	Biological Process	IDA (10353611)
GO:0042326	negative regulation of phosphorylation	Biological Process	IDA (8259215\|10208428)
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process	IDA (8259215)
GO:0007050	cell cycle arrest	Biological Process	IMP (15582998\|16243918)
GO:0006919	caspase activation	Biological Process	IMP (12082630)
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IDA (10208428)
GO:0001953	negative regulation of cell-matrix adhesion	Biological Process	IMP (10205165)
GO:0006309	DNA fragmentation during apoptosis	Biological Process	IMP (12082630)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006364	rRNA processing	Biological Process	IEA
GO:0006469	negative regulation of protein kinase activity	Biological Process	IMP (15582998)
GO:0006915	apoptosis	Biological Process	IEA
GO:0006917	induction of apoptosis	Biological Process	IDA (10208428)
GO:0006917	induction of apoptosis	Biological Process	IMP (12082630)
GO:0000075	cell cycle checkpoint	Biological Process	IMP (16243918)