ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

12578

Symbol:

Cdkn2a

Full Name:

cyclin-dependent kinase inhibitor 2A

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C3-C6|4 42.7 cM

Physical Location:

88920376-88940522 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1029 Symbol (Name): CDKN2A (cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4))

Ortholog Status:

The human GeneID 1029 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws2	Chronic Alcohol Withdrawal	4		33-51 (cM)	2.3	0.005	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001040654.1	NP_001035744.1	NC_000070.5 range: 88920376..88940522, complement
NM_009877.2	NP_034007.1	NC_000070.5 range: 88920376..88940522, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (12154087)
GO:0001652	granular component	Cellular Component	IDA (12154087)
GO:0005730	nucleolus	Cellular Component	IDA (11718560\|12154087\|15567177\|15989966\|16199867)
GO:0005654	nucleoplasm	Cellular Component	IDA (12154087)
GO:0005634	nucleus	Cellular Component	IEA
GO:0055105	ubiquitin-protein ligase inhibitor activity	Molecular Function	IDA (9878046)
GO:0005515	protein binding	Molecular Function	IPI (17274640)
GO:0004861	cyclin-dependent protein kinase inhibitor activity	Molecular Function	IDA (7651726\|12130539)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	RCA (12466851)
GO:0003700	transcription factor activity	Molecular Function	IDA (12154087)
GO:0003700	transcription factor activity	Molecular Function	RCA (12466851)
GO:0030308	negative regulation of cell growth	Biological Process	IMP (12154087)
GO:0030889	negative regulation of B cell proliferation	Biological Process	IMP (15964995)
GO:0031647	regulation of protein stability	Biological Process	IMP (12154087)
GO:0033088	negative regulation of immature T cell proliferation in the thymus	Biological Process	IMP (15964995)
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	Biological Process	IC (9878046)
GO:0045786	negative regulation of cell cycle	Biological Process	IEA
GO:0048103	somatic stem cell division	Biological Process	IMP (15964995)
GO:0051444	negative regulation of ubiquitin-protein ligase activity	Biological Process	IDA (9878046)
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process	IDA (12130539)
GO:0010468	regulation of gene expression	Biological Process	IMP (11438662)
GO:0008544	epidermis development	Biological Process	IMP (11551927)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (12154087)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	RCA (12466851)
GO:0006364	rRNA processing	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0007050	cell cycle arrest	Biological Process	IDA (7651726)
GO:0007568	aging	Biological Process	IMP (11551927)
GO:0007569	cell aging	Biological Process	IDA (11748239)
GO:0000079	regulation of cyclin-dependent protein kinase activity	Biological Process	IDA (7651726)