ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Xpo1

Full Name:

exportin 1, CRM1 homolog (yeast)

Alias:

AA420417|Crm1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 A3.2

Physical Location:

23156040-23197596 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7514 Symbol (Name): XPO1 (exportin 1 (CRM1 homolog, yeast))

Ortholog Status:

The human GeneID 7514 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AW123788
Fold Change:		1.5, 1.6, NC, 1.3
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Information

Original ID1:		Xpo1
Original ID2:		AW123788

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005643	nuclear pore	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0008565	protein transporter activity	Molecular Function	IDA (12446771)
GO:0005515	protein binding	Molecular Function	IPI (15767664)
GO:0005488	binding	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	IEA
GO:0042176	regulation of protein catabolic process	Biological Process	IMP (15767664)
GO:0015031	protein transport	Biological Process	IEA
GO:0000059	protein import into nucleus, docking	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006611	protein export from nucleus	Biological Process	IMP (15767664\|16316410\|16459298)
GO:0006611	protein export from nucleus	Biological Process	IDA (11796723\|12446771)
GO:0051028	mRNA transport	Biological Process	IEA