Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:10521
Full Name:DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
Organism:Homo sapiens (Human)
Genetic Location:22q13.1
Physical Location:37209388-37232290 on NC_000022.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.528305
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001098504.1NP_001091974.1NC_000022.9 range: 37209388..37232290, complement
NM_001098505.1NP_001091975.1NC_000022.9 range: 37209388..37232290, complement
NM_006386.4NP_006377.2NC_000022.9 range: 37209388..37232290, complement
NM_030881.3NP_112020.1NC_000022.9 range: 37209388..37232290, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentTAS (8871553)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003723RNA bindingMolecular FunctionTAS (8871553)
GO:0003724RNA helicase activityMolecular FunctionTAS (8871553)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0008026ATP-dependent helicase activityMolecular FunctionIEA
GO:0008186RNA-dependent ATPase activityMolecular FunctionTAS (8871553)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0006396RNA processingBiological ProcessTAS (8871553)
Other Database Cross Links
NCBI Entrez Gene:10521
HuGE Navigator:10521